Year of discovery :
Data not available.
Synthesis route :
2-methoxy-3-isopropyl Pyrazine is part of a family of molecules which scent is close to peanuts as well as cooked and roasted fruits. Pyrazines are often obtained with a Gutknecht or Gastaldi condensation reaction, in both cases to condense two amines on two ketones, under the effect of an acid and oxidation. Here, one of the reagents contains both methoxy and isopropyl groups of the final molecule, while the other does not have any branches.
Another synthesis way, in two steps, consists in reacting Glycoxal with Norvaline amide hydrochloride, to form 2-hydroxy-3-propyl Pyrazine. The second step makes this intermediairy react with diazomethane, to provoke its ethylation.
Synthesis precursor :
2-methoxy-3-isopropyl Pyrazine is not a precursor for the synthesis of another olfactive compound.
Isomerism :
During the synthesis of 2-methoxy-3-isopropyl Pyrazine, two other compounds are formed : 2-methoxy-5-isopropyl Pyrazine and 2-methoxy-6-isopropyl Pyrazine. These two molecules have a similar smell as their isomer.
Natural availability :
2-methoxy-3-isopropyl Pyrazine can be found in common plants as aspargus, peas and cucumber, but is not extracted from these plants for its use in perfumes.
Comments :